It's going to be more than an hour's worth of walking, and generally, not worth it if you're trying to get to class on time. So, your best bet is to take the 1 Train to Franklin Street or Chambers Street (I need to know where your school is first to give better directions but those are the primary stops in the heart of Tribeca). You can take the 28th Street, 23rd Street, or 18th Street 1 train, as those stops all service Chelsea's borders.