There are a group of us going out on Saturday night for a friends birthday. We can decide where to go. Any suggestions for a place with Food and Drink (and entertainment) that would be good for a group of about 16 people.

Try America it's right off Union Square around 15th street....very, very roomy....has a fun tilt to it....

Go to Tortilla Flats on W. 12th and Greenwich!! It's a Mexican place.
I've had many good parties there...great for Birthdays,
Call ahead to reserve enough space though.
You'll have a great time.